Thailanstatin A ( —— )

产品货号. M28204 CAS No. 1426953-21-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Thailanstatin A
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Thailanstatin A 是一种超强效的真核 RNA 剪接抑制剂 ( IC 50 =650 nM)。
产品描述

Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing ( IC 50 =650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC 50 s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC .(In Vitro):Thailanstatin A (TST-A) is a potent antiproliferative natural product discovered by our group from Burkholderia thailandensis MSMB43 . Thailanstatin A (DU-145, NCI-H232A, MDA-MB-231 and SKOV-3 cells) exhibits potent antiproliferative activities with GI 50 s in the single nM range (1.11-2.69 nM) .
体外实验

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体内实验

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同义词

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通路

Others
靶点

Other Targets
受体

AChR|Antifection|COX-2|PPAR
研究领域

——
适应症

——

CAS Number

1426953-21-0
分子量

535.63
分子式

C28H41NO9
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 250 mg/mL (466.74 mM)
SMILES

C[C@@H](/C=C\C(N[C@H]1[C@@H](C)O[C@@H](C/C=C(\C)/C=C/[C@H]([C@H]2O)O[C@H](CC(O)=O)C[C@]22OC2)[C@@H](C)C1)=O)OC(C)=O
化学全称

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1.Bourjot M, et al. Chemical constituents of Anacolosa pervilleana and their antiviral activities. Fitoterapia. 2012 Sep;83(6):1076-80.

计算器

产品手册

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